منابع مشابه
When is cAMP not cAMP? Effects of compartmentalization.
Many important cellular processes are controlled via stimulation (or inhibition) of signal transduction systems, among which heptahelical G protein– coupled receptors (GPCRs) figure prominently. A classical example in cardiac myocytes is the b-adrenergic receptor (b-AR) cascade (see Figure, panel A), which leads to positive inotropic and lusitropic effects.1 Occupation of the b-ARs by an agonis...
متن کاملModeling of glucose-induced cAMP oscillations in pancreatic β cells: cAMP rocks when metabolism rolls.
Recent advances in imaging technology have revealed oscillations of cyclic adenosine monophosphate (cAMP) in insulin-secreting cells. These oscillations may be in phase with cytosolic calcium oscillations or out of phase. cAMP oscillations have previously been modeled as driven by oscillations in calcium, based on the known dependence of the enzymes that generate cAMP (adenylyl cyclase) and deg...
متن کاملCompetitive cAMP antagonists for cAMP-receptor proteins.
The two exocyclic oxygen atoms at phosphorus of cAMP have been replaced by a sulfur atom or by a dimethylamino group. These substitutions introduce chirality at the phosphorus atom; therefore, two diastereoisomers are known for each derivative: (SP)-cAMPS, (RP)-cAMPS, (SP)-cAMPN(CH3)2, and RP-cAMPN(CH3)2. We have investigated the agonistic and antagonistic activities of these compounds in four ...
متن کاملcAMP-dependent protein kinase activation lowers hepatocyte cAMP.
Rat hepatocyte protein kinase was activated by incubating the cells with various cAMP analogs. Boiled extracts were then prepared and Sephadex G-25 chromatography was carried out. The G-25 procedure separated the analogs from cAMP since the resin had the unexpected property of binding cyclic nucleotides with differing affinities. Separation was necessary because the analogs would otherwise inte...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2001
ISSN: 0009-7330,1524-4571
DOI: 10.1161/res.89.5.373